Comparison of upfront tandem autologous-allogeneic transplantation versus reduced intensity allogeneic transplantation for multiple myeloma.
Identifieur interne : 000267 ( Main/Exploration ); précédent : 000266; suivant : 000268Comparison of upfront tandem autologous-allogeneic transplantation versus reduced intensity allogeneic transplantation for multiple myeloma.
Auteurs : F. Sahebi [États-Unis] ; S. Iacobelli [Italie] ; A V Biezen [Pays-Bas] ; L. Volin [Finlande] ; P. Dreger [Allemagne] ; M. Michallet [France] ; P T Ljungman [Suède] ; T. De Witte [Pays-Bas] ; A. Henseler [Pays-Bas] ; N P M. Schaap [Pays-Bas] ; L. L Pez-Corral [Espagne] ; X. Poire [Belgique] ; J. Passweg [Suisse] ; R-M Hamljadi [Algérie] ; S H Thomas [États-Unis] ; S. Schonland [Allemagne] ; G. Gahrton [Suède] ; C. Morris [Royaume-Uni] ; N. Kröger [Allemagne] ; L. Garderet [France]Source :
- Bone marrow transplantation [ 1476-5365 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allogreffes (MeSH), Autogreffes (MeSH), Femelle (MeSH), Humains (MeSH), Myélome multiple (mortalité), Myélome multiple (thérapie), Mâle (MeSH), Sujet âgé (MeSH), Survie sans rechute (MeSH), Taux de survie (MeSH), Transplantation de cellules souches hématopoïétiques (MeSH), Études de suivi (MeSH), Études rétrospectives (MeSH).
- MESH :
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Allografts (MeSH), Autografts (MeSH), Disease-Free Survival (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Hematopoietic Stem Cell Transplantation (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Multiple Myeloma (mortality), Multiple Myeloma (therapy), Retrospective Studies (MeSH), Survival Rate (MeSH).
- MESH :
- mortality : Multiple Myeloma.
- therapy : Multiple Myeloma.
- Adult, Aged, Allografts, Autografts, Disease-Free Survival, Female, Follow-Up Studies, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate.
Abstract
We performed a retrospective analysis of the European Group for Blood and Marrow Transplantation database comparing the outcomes of multiple myeloma patients who received tandem autologous followed by allogeneic PSCT (auto-allo) with the outcomes of patients who underwent a reduced intensity conditioning allograft (early RIC) without prior autologous transplant. From 1996 to 2013, we identified a total of 690 patients: 517 patients were planned to receive auto-allo and 173 received an early RIC allograft without prior autologous transplant. With a median follow-up of 93 months, 5-year PFS survival was significantly better in the auto-allo group, 34% compared with 22% in the early RIC group (P<0.001). OS was also significantly improved in the auto-allo group with a 5-year rate of 59% vs 42% in the early RIC group (P=0.001). The non-relapse mortality rate was lower in the auto-allo group than in the early RIC group, with 1- and 3-year rates of 8% and 13% vs 20% and 28%, respectively (P<0.001). The relapse/progression rate was similar in the two groups, with 5-year rates of 50% for auto-allo and 46% for early RIC (P=0.42). These data suggest that planned tandem autologous allograft can improve overall survival compared with upfront RIC allograft alone in patients with multiple myeloma.
DOI: 10.1038/bmt.2015.45
PubMed: 25798673
Affiliations:
- Algérie, Allemagne, Belgique, Espagne, Finlande, France, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Californie, District de Karlsruhe, Gueldre, Hambourg, Hollande-Méridionale, Irlande du Nord, Latium, Rhône-Alpes, Région de Bruxelles-Capitale, Svealand, Wilaya d'Alger, Île-de-France
- Alger, Bruxelles, Hambourg, Heidelberg, Leyde, Lyon, Nimègue, Paris, Rome, Stockholm
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Le document en format XML
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De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Henseler, A" sort="Henseler, A" uniqKey="Henseler A" first="A" last="Henseler">A. Henseler</name><affiliation wicri:level="3"><nlm:affiliation>EBMT, University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EBMT, University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schaap, N P M" sort="Schaap, N P M" uniqKey="Schaap N" first="N P M" last="Schaap">N P M. 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Poire</name><affiliation wicri:level="3"><nlm:affiliation>Cliniques Universitaires Saint-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaires Saint-Luc, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Passweg, J" sort="Passweg, J" uniqKey="Passweg J" first="J" last="Passweg">J. Passweg</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hamljadi, R M" sort="Hamljadi, R M" uniqKey="Hamljadi R" first="R-M" last="Hamljadi">R-M Hamljadi</name><affiliation wicri:level="3"><nlm:affiliation>Centre Pierre et Marie Curie, Alger, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Centre Pierre et Marie Curie, Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Thomas, S H" sort="Thomas, S H" uniqKey="Thomas S" first="S H" last="Thomas">S H Thomas</name><affiliation wicri:level="2"><nlm:affiliation>City of Hope, Duarte, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope, Duarte, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schonland, S" sort="Schonland, S" uniqKey="Schonland S" first="S" last="Schonland">S. Schonland</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Gahrton, G" sort="Gahrton, G" uniqKey="Gahrton G" first="G" last="Gahrton">G. Gahrton</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Morris, C" sort="Morris, C" uniqKey="Morris C" first="C" last="Morris">C. Morris</name><affiliation wicri:level="2"><nlm:affiliation>Queens University of Belfast, Belfast, Northern Ireland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Queens University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Kroger, N" sort="Kroger, N" uniqKey="Kroger N" first="N" last="Kröger">N. Kröger</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garderet, L" sort="Garderet, L" uniqKey="Garderet L" first="L" last="Garderet">L. Garderet</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25798673</idno><idno type="pmid">25798673</idno><idno type="doi">10.1038/bmt.2015.45</idno><idno type="wicri:Area/PubMed/Corpus">000548</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000548</idno><idno type="wicri:Area/PubMed/Curation">000546</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000546</idno><idno type="wicri:Area/PubMed/Checkpoint">000544</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000544</idno><idno type="wicri:Area/Main/Merge">000267</idno><idno type="wicri:Area/Main/Curation">000267</idno><idno type="wicri:Area/Main/Exploration">000267</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of upfront tandem autologous-allogeneic transplantation versus reduced intensity allogeneic transplantation for multiple myeloma.</title><author><name sortKey="Sahebi, F" sort="Sahebi, F" uniqKey="Sahebi F" first="F" last="Sahebi">F. Sahebi</name><affiliation wicri:level="2"><nlm:affiliation>1] City of Hope, Duarte, CA, USA [2] Southern California Kaiser Permanente, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] City of Hope, Duarte, CA, USA [2] Southern California Kaiser Permanente, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Iacobelli, S" sort="Iacobelli, S" uniqKey="Iacobelli S" first="S" last="Iacobelli">S. Iacobelli</name><affiliation wicri:level="3"><nlm:affiliation>Università Tor Vergata, Roma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Università Tor Vergata, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Biezen, A V" sort="Biezen, A V" uniqKey="Biezen A" first="A V" last="Biezen">A V Biezen</name><affiliation wicri:level="3"><nlm:affiliation>EBMT, University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EBMT, University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Volin, L" sort="Volin, L" uniqKey="Volin L" first="L" last="Volin">L. Volin</name><affiliation wicri:level="1"><nlm:affiliation>Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Dreger, P" sort="Dreger, P" uniqKey="Dreger P" first="P" last="Dreger">P. Dreger</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Michallet, M" sort="Michallet, M" uniqKey="Michallet M" first="M" last="Michallet">M. Michallet</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital E. Herriot, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital E. Herriot, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Ljungman, P T" sort="Ljungman, P T" uniqKey="Ljungman P" first="P T" last="Ljungman">P T Ljungman</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="De Witte, T" sort="De Witte, T" uniqKey="De Witte T" first="T" last="De Witte">T. De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Henseler, A" sort="Henseler, A" uniqKey="Henseler A" first="A" last="Henseler">A. Henseler</name><affiliation wicri:level="3"><nlm:affiliation>EBMT, University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EBMT, University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schaap, N P M" sort="Schaap, N P M" uniqKey="Schaap N" first="N P M" last="Schaap">N P M. Schaap</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="L Pez Corral, L" sort="L Pez Corral, L" uniqKey="L Pez Corral L" first="L" last="L Pez-Corral">L. L Pez-Corral</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Poire, X" sort="Poire, X" uniqKey="Poire X" first="X" last="Poire">X. Poire</name><affiliation wicri:level="3"><nlm:affiliation>Cliniques Universitaires Saint-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaires Saint-Luc, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Passweg, J" sort="Passweg, J" uniqKey="Passweg J" first="J" last="Passweg">J. Passweg</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hamljadi, R M" sort="Hamljadi, R M" uniqKey="Hamljadi R" first="R-M" last="Hamljadi">R-M Hamljadi</name><affiliation wicri:level="3"><nlm:affiliation>Centre Pierre et Marie Curie, Alger, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Centre Pierre et Marie Curie, Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Thomas, S H" sort="Thomas, S H" uniqKey="Thomas S" first="S H" last="Thomas">S H Thomas</name><affiliation wicri:level="2"><nlm:affiliation>City of Hope, Duarte, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope, Duarte, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schonland, S" sort="Schonland, S" uniqKey="Schonland S" first="S" last="Schonland">S. Schonland</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Gahrton, G" sort="Gahrton, G" uniqKey="Gahrton G" first="G" last="Gahrton">G. Gahrton</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Morris, C" sort="Morris, C" uniqKey="Morris C" first="C" last="Morris">C. Morris</name><affiliation wicri:level="2"><nlm:affiliation>Queens University of Belfast, Belfast, Northern Ireland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Irlande du Nord</region></placeName><wicri:cityArea>Queens University of Belfast, Belfast</wicri:cityArea></affiliation></author><author><name sortKey="Kroger, N" sort="Kroger, N" uniqKey="Kroger N" first="N" last="Kröger">N. Kröger</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Garderet, L" sort="Garderet, L" uniqKey="Garderet L" first="L" last="Garderet">L. Garderet</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Bone marrow transplantation</title><idno type="eISSN">1476-5365</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Allografts (MeSH)</term><term>Autografts (MeSH)</term><term>Disease-Free Survival (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Hematopoietic Stem Cell Transplantation (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multiple Myeloma (mortality)</term><term>Multiple Myeloma (therapy)</term><term>Retrospective Studies (MeSH)</term><term>Survival Rate (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allogreffes (MeSH)</term><term>Autogreffes (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Myélome multiple (mortalité)</term><term>Myélome multiple (thérapie)</term><term>Mâle (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Survie sans rechute (MeSH)</term><term>Taux de survie (MeSH)</term><term>Transplantation de cellules souches hématopoïétiques (MeSH)</term><term>Études de suivi (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Allografts</term><term>Autografts</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Hematopoietic Stem Cell Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allogreffes</term><term>Autogreffes</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Taux de survie</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a retrospective analysis of the European Group for Blood and Marrow Transplantation database comparing the outcomes of multiple myeloma patients who received tandem autologous followed by allogeneic PSCT (auto-allo) with the outcomes of patients who underwent a reduced intensity conditioning allograft (early RIC) without prior autologous transplant. From 1996 to 2013, we identified a total of 690 patients: 517 patients were planned to receive auto-allo and 173 received an early RIC allograft without prior autologous transplant. With a median follow-up of 93 months, 5-year PFS survival was significantly better in the auto-allo group, 34% compared with 22% in the early RIC group (P<0.001). OS was also significantly improved in the auto-allo group with a 5-year rate of 59% vs 42% in the early RIC group (P=0.001). The non-relapse mortality rate was lower in the auto-allo group than in the early RIC group, with 1- and 3-year rates of 8% and 13% vs 20% and 28%, respectively (P<0.001). The relapse/progression rate was similar in the two groups, with 5-year rates of 50% for auto-allo and 46% for early RIC (P=0.42). These data suggest that planned tandem autologous allograft can improve overall survival compared with upfront RIC allograft alone in patients with multiple myeloma. </div></front></TEI><affiliations><list><country><li>Algérie</li><li>Allemagne</li><li>Belgique</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Karlsruhe</li><li>Gueldre</li><li>Hambourg</li><li>Hollande-Méridionale</li><li>Irlande du Nord</li><li>Latium</li><li>Rhône-Alpes</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li><li>Wilaya d'Alger</li><li>Île-de-France</li></region><settlement><li>Alger</li><li>Bruxelles</li><li>Hambourg</li><li>Heidelberg</li><li>Leyde</li><li>Lyon</li><li>Nimègue</li><li>Paris</li><li>Rome</li><li>Stockholm</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Sahebi, F" sort="Sahebi, F" uniqKey="Sahebi F" first="F" last="Sahebi">F. Sahebi</name></region><name sortKey="Thomas, S H" sort="Thomas, S H" uniqKey="Thomas S" first="S H" last="Thomas">S H Thomas</name></country><country name="Italie"><region name="Latium"><name sortKey="Iacobelli, S" sort="Iacobelli, S" uniqKey="Iacobelli S" first="S" last="Iacobelli">S. Iacobelli</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Biezen, A V" sort="Biezen, A V" uniqKey="Biezen A" first="A V" last="Biezen">A V Biezen</name></region><name sortKey="De Witte, T" sort="De Witte, T" uniqKey="De Witte T" first="T" last="De Witte">T. De Witte</name><name sortKey="Henseler, A" sort="Henseler, A" uniqKey="Henseler A" first="A" last="Henseler">A. Henseler</name><name sortKey="Schaap, N P M" sort="Schaap, N P M" uniqKey="Schaap N" first="N P M" last="Schaap">N P M. Schaap</name></country><country name="Finlande"><noRegion><name sortKey="Volin, L" sort="Volin, L" uniqKey="Volin L" first="L" last="Volin">L. Volin</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Dreger, P" sort="Dreger, P" uniqKey="Dreger P" first="P" last="Dreger">P. Dreger</name></region><name sortKey="Kroger, N" sort="Kroger, N" uniqKey="Kroger N" first="N" last="Kröger">N. Kröger</name><name sortKey="Schonland, S" sort="Schonland, S" uniqKey="Schonland S" first="S" last="Schonland">S. Schonland</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Michallet, M" sort="Michallet, M" uniqKey="Michallet M" first="M" last="Michallet">M. Michallet</name></region><name sortKey="Garderet, L" sort="Garderet, L" uniqKey="Garderet L" first="L" last="Garderet">L. Garderet</name></country><country name="Suède"><region name="Svealand"><name sortKey="Ljungman, P T" sort="Ljungman, P T" uniqKey="Ljungman P" first="P T" last="Ljungman">P T Ljungman</name></region><name sortKey="Gahrton, G" sort="Gahrton, G" uniqKey="Gahrton G" first="G" last="Gahrton">G. Gahrton</name></country><country name="Espagne"><noRegion><name sortKey="L Pez Corral, L" sort="L Pez Corral, L" uniqKey="L Pez Corral L" first="L" last="L Pez-Corral">L. L Pez-Corral</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Poire, X" sort="Poire, X" uniqKey="Poire X" first="X" last="Poire">X. Poire</name></region></country><country name="Suisse"><noRegion><name sortKey="Passweg, J" sort="Passweg, J" uniqKey="Passweg J" first="J" last="Passweg">J. Passweg</name></noRegion></country><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Hamljadi, R M" sort="Hamljadi, R M" uniqKey="Hamljadi R" first="R-M" last="Hamljadi">R-M Hamljadi</name></region></country><country name="Royaume-Uni"><region name="Irlande du Nord"><name sortKey="Morris, C" sort="Morris, C" uniqKey="Morris C" first="C" last="Morris">C. Morris</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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